Protein Details: Transient receptor potential cation channel subfamily M member 8
Protein ID
ICDB_Pro_1301
Protein Name
Transient receptor potential cation channel subfamily M member 8
Gene Name
Trpm8 Cmr1
Organism
Rattus norvegicus (Rat)
Length
1104 amino acids
AlphaFoldDB
AF-Q8R455-F1-model_v4.pdb
Function
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1038/nature719; 10.1152/jn.00843.2002; 10.1074/jbc.m807228200; 10.1016/j.bbrc.2010.03.027
RefSeq
NP_599198.2